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Sedative action CBD effects on What Does Hemp Seed Oil Do For Your Skin anxiety psychoses and movement disorders (1980’s and 1990’s) After the peak of reports on CBD in the 1970’s the next two decades the publication rate remained stabilized indicating a lower degree of interest on the study of therapeutic actions of CBD. The reports in this field were maintained mainly by Brazilian researchers investigating the anxiolytic and
dr. rick simpson hemp oil antipsychotic properties of CBD and by a few studies about its effects in motor diseases conducted by Consroe et al.4849 1. Anxiolytic action In 1974 an interactive study between CBD and THC per os in healthy volunteers gave the first clue that CBD could act as an anxiolytic drug.22 This study showed that CBD (60 mg) added to delta9-THC (30 mg) changed the symptoms induced by does thc block dopamine receptors delta9-THC alone in such a way that the subjects receiving the mixture showed less anxiety and more pleasurable effects. In 1982 a study with appropriae rating scales hemp oil buy uk confirmed that CBD (1 mg/kg) co-administered with delta9-THC (0.5 mg/kg) significantly reduced anxiety indexes in healthy volunteers.46 The anxiolytic properties of CBD have been demonstrated by several pre-clinical studies that employed different paradigms such as the conditioned emotional response50 the Vogel conflict test51 and the elevated plus-maze.5253 In the latter study53 the effective doses of CBD ranged from 2.5 to 10 mg/kg and the drug produced an inverted U-shaped dose-response curve the higher doses being no longer effective. This could explain the negative results obtained with high doses of CBD (above 100 mg/kg) in a
previous study employing the Geller-Seifter conflict test.54 A recent study showed that the anxiolytic effect of CBD in the Vogel test was not mediated by benzodiazepine receptors.55 2. Antipsychotic action The first evidence that CBD could have antipsychotic effects was obtained in the interactive study of CBD and delta9-THC in healthy volunteers published in 1982.46 This study demonstrated that CBD could inhibit THC-induced subjective changes that resembled symptoms of cannabinoid anandamide psychotic diseases such as: disconnected thought perceptual disturbance What Does Hemp Seed Oil Do For Your Skin depersonalization and resistance to communication. In the same year it was observed that patients What Does Hemp Seed Oil Do For Your Skin admitted to a psychiatric hospital in South Africa after the use of a variety of cannabis virtually devoid of CBD showed much higher frequency of acute psychotic episodes than in other countries.