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But what happens when you combine two does thc block dopamine receptors psychoactive substances: marijuana and caffeine? The effects of using these two substances in combination have not been heavily researched said Dr. Scott Krakower the assistant unit chief of psychiatry at Zucker Hillside Hospital in New Hyde Park New York. But using two drugs in combination can always potentially be a problem he said. There is some evidence from lab and animal studies that suggests that taken together caffeine and marijuana “would mix neuro-chemically” Krakower told Live cannabinoid melting point Science.