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In addition we showed that CBD reduces mitochondrial membrane potential Legal High Cbd Vape triggers the translocation of BID to the mitochondria the release of cytochrome c to the cytosol and ultimately the activation of the intrinsic apoptotic pathway in breast cancer cells. CBD increased the generation of reactive oxygen species (ROS) and ROS inhibition blocked the induction of apoptosis and autophagy. Our study revealed an intricate interplay between apoptosis and autophagy in CBD-treated breast cancer
cells and highlighted the value of continued investigation into the potential use of CBD as an antineoplastic agent. Mol Cancer Ther; 10(7); 1161-72.
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A concentration-dependent increase in the Annexin V-positive cells was observed in CBD-treated estrogen Legal High Cbd Vape receptor+ve and estrogen receptor?ve breast order vape cannabidiol cartridges cancer cells indicating induction of apoptosis in all cell lines examined ( Fig. 1B ). We also compared the effects of CBD on the viability of MDA-MB-231 breast cancer cells and MCF-10A cells a nontumorigenic human mammary epithelial cell line ( 19 ).
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