NIH is the federal government’s center of biomedical research. The PDQ summaries are based on an independent review of the medical literature. They are not policy statements of the NCI or the NIH. Cbd Rich Hemp Oil Legal purpose of This Summary This PDQ cancer information summary has current information about the use of Cannabis and cannabinoids in the rick simpson oil official site treatment of people with cancer.
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enzymes. 30 Recently it was found to be an antagonist at the putative new cannabinoid receptor GPR55 a GPCR expressed in the caudate nucleus and putamen 31 Cannabidiol has also been shown to act as a 5-HT1A receptor partial agonist 32 an action which may be involved in its antidepressant 33 34 anxiolytic 34 35 and neuroprotective 36 37 effects. Cannabidiol is an allosteric modulator of ? and ?-opioid receptors 38 Cannabidiol’s pharmacological effects have also been attributed to PPAR-? receptor agonism and intracellular calcium release 5 Research suggests that CBD may exert some of its pharmacological action through its inhibition of FAAH which may in turn increase the levels of endocannabinoids such as anandamide produced by the body. 39 There is some preclinical evidence to suggest that cannabidiol may reduce THC clearance modestly increasing THC’s plasma concentrations resulting in a greater amount of THC available to receptors increasing the effect of THC in a dose-dependent manner.