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Neurosci Lett 346: 61-64. Cannabinoids And Ovarian Cancer carchman RA Harris LS and Munson AE (1976) The inhibition of DNA synthesis by cannabinoids. Cancer Res 36: 95-100.

However the amount of these non-essential fatty acids varies according to the quality of the hemp plant the acids were derived from. Protein Content Hemp oil is comprised of 25 percent protein says Dr. Andrew Weil the program director for the Arizona Center for Integrative Medicine which is recognized by the Arizona Board of Regents. This high-quality protein provides amino acids in ratios similar to the protein in meats and eggs. The structure of hemp oil proteins makes them easily digestible.

Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors. Proc Natl Acad Sci USA 96: 14136-14141. Killestein cbd oil bipolar disorder J Hoogervorst ELJ Reif M Blauw B Smits M Uitdehaag BMJ Nagelkerken L and Polman CH (2003) Immunomodulatory effects of orally administered cannabinoids in multiple sclerosis.

It is not unknown for male plants to produce feminine flowers making it possible for the plant to self-pollinate produce seeds and ensure the survival of the species for another generation. However it is far more common for a female plant to produce male flowers for the same purpose. This fantastic survival trait is not only useful for the plant but has now been turned to the advantage of people who wish to grow it. Rather than being produced from male spore meeting female flower feminized seeds are the result of forcing a female plant to produce pollen and then using this to fertilize another female. The resulting seeds lack male chromosomes so when they are grown out each plant will produce female flowers and growth characteristics.

The oil is also not suitable for cooking because it has a very low smoking point. Refined hemp oil is much more shelf stable although many of the benefits of it are not present after refining. Hemp is a controversial crop in some regions of the world due to buy cannabinoid oil for sale concerns about psychoactive plants in the Cannabis genus.

Taxing marijuana sales will raisemillions ofdollars in new revenue each year most of which will be allocated topublic education. Legitimate marijuana businesses will create thousands of good jobs for Arizonaresidents andutilize the products and services of other Arizonabusinesses. Former police officer: Prohibition hasn’t worked but at least one state has a solution. would love to have you moderate a live debate on MJ prohibition in AZ! Latest News?Can Hemp Oil Reduce Seizures Related to Autism? I read about hemp oil for preventing seizures in children and adults with autism.

Encouragingly some responded well to medical order cannabidiol oil uk Cannabinoids And Ovarian Cancer cbd oil spray review marijuana. They experienced fewer seizures. What about hash oil vapor pen CBD? Recently researchers used an online survey to get information from 19 parents who were using a CBD-enriched strain of marijuana to treat children with severe epilepsy disorders.

Sort by: Featured Items Newest Items Buy Hemp CBD (Cannabidiol) Oil Earth Science Tech Inc. (ETST)”High Grade CBD Rich Hemp Oil” contains hundreds of micronutrients (phytonutrients). Modern science has identified over 400 phytonutrients in various parts of the industrial hemp plant. These include hundreds of Terpenoids Essential Oils and Antioxidants but perhaps the most dynamic are a group of 80 compounds called Cannabinoids that are exclusively found in Hemp and one other place; our Cannabinoids And Ovarian Cancer cbd extraction from cannabis cbd bodies. ETST High Grade CBD Rich Hemp Oilcontains all the synergistic Cannabinoids Terpenoids Essential Oils and other compounds of the original plant. There are roughly 80 different phyto-cannabinoids most prominently CBD CBC CBG CBN and most likely others yet to be effectively identified.

However depending on your illness it is recommended that you conduct your own research using resources such as PubMed. These statements have not been evaluated by the FDA. FOOD AND DRUG ADMINISTRATION (FDA) DISCLOSURE These statements have not been evaluated by the FDA and are not intended to diagnose treat or cure any disease.

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These results support our finding that CBD inhibits AKT/mTOR/4EBP1 a critical oncogenic what are the side effects of weed withdrawal pathway. Hemp Seed Oil Cannabidiol Vape cBD induces apoptosis in MDA-MB-231 cells via the mitochondria-mediated signaling pathway Because we observed apoptosis in CBD-treated breast cancer cells we explored further the molecular mechanisms involved in the CBD-mediated apoptosis cannabidiol side effects of smoking weed short term cannabinoid lakewood wa review of MDA-MB-231 cells. Signaling by

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both mitochondria-mediated and death receptor-mediated pathways converge at caspases -7 -9 and/or -3 ( 25 ). Thus we examined the effect of CBD on the cleavage of procaspases -3 -7 and -9 into the smaller caspases -3 -7 and -9 respectively by Western blot analysis. We observed a concentration-dependent increase in all 3 cleaved caspases after CBD treatment ( Fig. 4A ). Figure 4.

We analyzed the effects of CBD on breast cancer cells by using both estrogen receptor+ve (MCF-7 and ZR-75-1) and estrogen Hemp Seed Oil Cannabidiol Vape receptor?ve (MDA-MB-231 and SK-BR-3) cell lines with an MTS viability assay. Cells were treated with CBD (0-10 ?mol/L) for 24 hours. CBD significantly decreased cell viability of both estrogen receptor+ve and estrogen receptor?ve cell lines in a concentration-dependent manner ( Fig. 1A ).

C ) suggesting that CBD may preferentially kill cancer cells versus normal cells. To determine whether CBD mediates cell death via CB1 CB2 or the vallinoid receptor we repeated the viability assay with 5 ?mol/L CBD and with 1 ?mol/L and 2 ?mol/L of the following antagonists: AM251 (selective for CB1) AM630 (selective for CB2) and capsazepine (selective for the vallinoid receptor). MDA-MB-231 cells treated with individual antagonists displayed viability levels equivalent to untreated cells (data not shown). Although treatment with CBD alone and in combination with either concentration of each antagonist resulted in significant loss of viability compared with untreated cells viability levels were order prana medical cbd gel caps nearly identical among all treatment combinations ( Fig. 1D ). We interpret these data to Hemp Seed Oil Cannabidiol Vape indicate that CBD-induced cytotoxicity in MDA-MB-231 cells occurs independent of these 3 receptors.

Purpose of This Summary This PDQ benefits of cbd oil for pain cancer information summary has current information about the use of Cannabis and cannabinoids in the treatment of people with cancer. It is meant to inform and help patients families and caregivers. It does not give formal guidelines or recommendations for making decisions about health care.

The health professional versions have detailed information Hemp Seed Oil Cannabidiol Vape written in technical language. The patient versions does smoking cannabidiol cause cancer 2017 are written in easy-to-understand nontechnical language. Both versions have cancer information that is accurate and up to date and most versions are also available in Spanish PDQ is a service of the NCI. The NCI is part of the National Institutes of Health (NIH).

Apoptotic pathways: paper wraps stone blunts scissors. Cell 2000;102:1-4. Life and death partners: apoptosis autophagy and the cross-talk between them.

The access restrictions did not prove to reduce risk to health and safety or to

improve access to marihuana – the purported objectives of the regulation? he wrote. The Canadian government must now decide if it will appeal the decision. Prime Minister Justin Trudeau elected in October pledged during his campaign to

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regulate and legalize recreational marijuana though his ruling Liberals have not addressed their plans for medical marijuana at length.

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Moreover cleaved BID can cooperate with other proapoptotic Bcl-2 members including Bax and/or Bak to enhance mitochondrial membrane permeabilization ( 25 ). In this study we observed a concentration-dependent CBD-induced elevation of Bax ( Fig. Order Hemp Oil Moisturizer 4C ); however Bak levels did not change (data not shown). In addition to intracellular death signaling mitochondria-based high cannabidiol wax apoptosis can be initiated by engaging various death signaling receptors on the cell surface including Fas-L and TRAIL ( 27 ). Order Hemp Oil Moisturizer To characterize more precisely the mechanisms of CBD-induced apoptosis we Order Hemp Oil Moisturizer examined by Western blot analysis the levels of Fas-L TRAIL pro-caspase-8 caspase-8 BID and t-BID in whole cell lysates of MDA-MB-231 cells after treatment with various concentrations of CBD. We observed a concentration-dependent increase in Fas-L expression ( Fig.

If you feel that something is wrong and would like to find hemp oil cures for cancer out what then some testing would be someting that can not be avoided. If you can relax and enjoy your time with her then maybe you should just do it. In… Help RareConnect Order Hemp Oil Moisturizer better buy cannabidiol seeds meet your needs by sharing your opinion is cbd legal in ga experience and preferences about our website. It will only take you a few minutes to complete 11 questions which can cbd gvhd 2017 really help us deliver you a better service.

Autophagy (cell recycling) is another normal physiological process by which the body breaks down unwanted cells. It maintains our homeostasis or balance by Order Hemp Oil Moisturizer aiding the degradation of old cells and the formation of new ones. Cannabinoids where can i buy cannabidiol oil in charleston sc the molecular family in which CBD belongs work by binding to certain cell receptors that make up the human endocannabinoidsystem These are the CB1 and CB2 receptors –

  1. Gateway drug The Gateway Hypothesis states that cannabis use increases the probability of trying “harder” drugs
  2. Some clinical trials are open only to patients who have not started treatment
  3. The patient versions are written in easy-to-understand nontechnical language
  4. Rett Syndrome have epilepsy and one-third of these a total of 20-25% has epilepsy which is very difficult to treat
  5. Blood may contain both substances with the relative amounts dependent on the recency and extent of usage
  6. The relationship between apoptotic and autophagic death is controversial ( 16 )
  7. It has also been shown to work with THC to reduce the size of tumors
  8. Epidiolex was given in gradually increasing doses alongside current AED treatment regimes of which patients were taking an average of three

. Interestingly the paper notes that CBD induced its anticancer effects independent of the activation of these receptors Order Hemp Oil Moisturizer prompting the authors to state that: Many cannabinoids mediate their effects by binding to CB1 CB2 or the vallinoid receptor (3 4); however our results indicate that CBD induces PCD independent of these receptors.

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Our broad range of products is a direct result of our commitment to maximizing the potential from the hemp plant. FDA Disclosure These statements have not been evaluated by the Food and Drug Administration (FDA). Order Butane Honey Oil Extraction these products and statements are not intended to diagnose treat cure or prevent any disease.

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CBD provides relief from inflammation pain anxiety psychosis seizures and spasms without the stoned effect. It has demonstrated benefits for those with a wide range of conditions including arthritis diabetes alcoholism multiple-sclerosis chronic pain schizophrenia post-traumatic stress disorder depression and epilepsy. The high-inducing effects of THC have cast a long shadow over the benefits rick simpson oil for cancer CBD could offer a patient or player and has contributed to the delay in legalizing medical marijuana according to Dr Bonni Goldstein the medical director of Ghost Group which specializes in treating pediatric seizures with medical cannabis. Legal Hemp Oil For Pets california was the first state to legalize medicinal marijuana; since then 23 more states allow doctors to prescribe marijuana as a therapy.

White said he has about a quarter acre of hemp this year. By 2017 he hopes to plant over 100 acres and begin producing Vermont-grown hemp oil. He believes in the buy can weed cure seizures nutritional value of hemp oil and has purchased and ingested it for years. His current plan is to produce nontherapuetic hemp oil but White said cbd oil portland oregon if he saw a need in the market to grow hemp for a medicinal purpose he might consider the option. Still he has reservations. “I wouldn’t want to jump through the hoops that a dispensary has to” he said.

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United States Controlled Substances Act (USA CDA). Cbd Bipolar 2017 the company does sell and distribute hemp-based products. Food and Drug Administration (FDA) Disclosure These statements have not been evaluated by the FDA and are not intended to diagnose treat or cure any disease. always check does hemp seeds contain thc with your physician before starting a new dietary supplement program. Leaving Our Website Disclaimer If we have a research link to a website where we sell products or have product information the exit disclaimer indicates that when you click ok you will leave the website and visit an external link. Links to any informational websites are provided solely as a service to our users. External links provide additional information that may be useful or interesting and has no affiliation to the promotion sale and distribution of Hemp Health Inc.

For more information please read our terms of use Most popular in: Epilepsy ADHD Alzheimer’s Disease Cholesterol Concussion Conjunctivitis (allergic) Conjunctivitis (infective) Coronavirus Infection Costello Syndrome Hay Fever Head Lice Heart Disease Heart Failure Hyperhidrosis (Excessive Sweating) Japanese Encephalitis Laryngitis Malaria Night terrors Noonan Syndrome Norovirus Infection Postherpetic Neuralgia Postpartum Depression Prader-Willi Syndrome Water Retention (Fluid Retention) Zika virus Zollinger-Ellison Cbd Bipolar 2017 Syndrome Suggested Reading This page was printed from: By clicking submit you agree to accept a cookie from Tocris Bioscience. For details please read our privacy and cookie policy nyl)-2-cyclohexen-1-yl-5-pentyl-13-benzenediol Biological Activity Non-psychotropic constituent of cannabis that is anticonvulsive antihyperalgesic and neuroprotective in vivo. GPR55 and weak CB1 antagonist (IC50 values are 0.445 and 3.35 ?M) CB2 receptor inverse agonist and inhibitor of anandamide uptake (IC50 = 27.5 ?M). Also a weak agonist at VR1 vanilloid receptors (EC50 = 3.

Tolerance and withdrawal Cannabis usually causes no tolerance or withdrawal symptoms except in heavy order cannabidiol oil dosage for crohn’s disease users. In a survey of heavy users 42.4% experienced withdrawal symptoms when they tried to quit marijuana such as craving irritability boredom anxiety and sleep disturbances. 86 About 9% of those who experiment with cannabidiol lung cancer review marijuana eventually become dependent. The rate goes up to 1 in 6 among those who begin use as adolescents and one quarter to one-half of those who use it daily according to a NIDA review.

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Along with marijuana intoxication Monte says marijuana-related cases include patients with underlying chronic conditions that have been exacerbated after consuming cannabis and those who have complications after using cannabis like getting into a car accident. While part of the rise of these emergency room visits can be attributed to increased openness in patients disclosing marijuana use to health professionals because of its legal status in the state Monte says the researchers were surprised at how drastically the number of visits from out-of-town patients increased Cbd Oil Kills Cancer 2017 relative cbd cannabinoid cancer

to other patients. Cbd Oil Kills Cancer 2017 one reason for the discrepancy could be the higher potency of industrially-cultivated marijuana and unfamiliarity with edible marijuana products
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for visitors from states where cannabis is outlawed. The marijuana you buy in Colorado may be a lot different than the marijuana people are used to? says Mike Van cannabis cancer cure hemp oil 2017 Dyke branch chief for environmental epidemiology at the CDPHE and co-author of the report. It is a lot more potent now than in the past especially when you’re using edibles.

The cannabinoids will take effect within 20 minutes and will last about 1 to 3 hours

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. What is CBD = Cannabidiol CBD = Cannabidiol CBD is a Natural Constituent from Marijuana and Industrialized Hemp Plants. The reason the CBD Store “you are here now” can sell these products online is because Cbd Oil cbd mechanism of action Kills Cancer 2017 CBD contained within the Hemp oil from Imported Industrialized Hemp Plants… Legal in all 50 states.

Van Dyke who contributed to Kim’s research runs a marijuana education project called Good to Know ( ) but he suspects it’s been more effective with Colorado residents than rick simpson oil brain cancer tourists. “Visitors are here for a short time and it’s hard to get to those people” Van Dyke said. The key to educating pot tourists he added is the conversation that happens between salespeople (known as “budtenders”) and consumers. He noted that it’s difficult to ensure Cbd Oil Kills Cancer 2017 that those conversations are being had.

The oil has to have been made from leaves and stems of hemp. If

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Cancer patients considering what are the side effects of quitting weed smoking complementary and alternative therapies should discuss this decision with their doctor nurse or pharmacist as they would any therapeutic approach because some complementary and alternative therapies may Cannabinoid Meeting 2014 interfere with their standard treatment or may be harmful when used with conventional treatment. Evaluation of CAM Approaches It is important how to make honey hash oil at home that the same rigorous scientific evaluation used to assess conventional approaches be used to evaluate CAM therapies. The National Cancer Institute and the National Center for Complementary and Integrative Health (NCCIH) are sponsoring a number of clinical trials (research studies) at medical centers to evaluate CAM therapies for cancer. Cannabinoid Meeting 2014 conventional approaches to cancer treatment have generally been studied for safety and effectiveness through a rigorous scientific process that includes clinical trials with large numbers of patients.

In the Netherlands chalk has been used to make cannabis appear to be of a higher quality. 141 Increasing the weight of hashish products in Germany with lead caused lead intoxication in at least

29 users. 142 Despite cannabis being generally perceived as a natural product 143 in a recent Australian survey 144 one in four Australians consider cannabis grown indoors under hydroponic conditions to be Cannabinoid Meeting 2014 a greater health risk due to increased contamination added to the plant during cultivation to enhance the plant growth and quality. Drug dealers may “spike” or lace marijuana with other chemicals such as PCP creating a product known as “wet marijuana”; this enhances the effects of smoking it 145 and it can be used to make low-grade low-potency marijuana seem more effective. Medical use Medical marijuana refers to the use of the Cannabis plant as a physician-recommended herbal therapy as well as synthetic 146 THC and cannabinoids.

C bars labeled BAF+CBD and CBD). We interpreted these data to indicate that apoptosis levels increase in CBD-treated breast cancer cells when autophagy is inhibited. To corroborate these findings we best cannabidiol e juice examined under the same conditions the levels of cleaved PARP and cleaved caspase-8 by Western blot analysis. We observed a decrease in cleaved PARP in MDA-MB-231 cells pretreated with a general caspase inhibitor before incubation with CBD as compared with those treated with CBD alone ( Fig.

The largest study presented Cannabinoid Meeting 2014 efficacy and safety data on Epidiolex over a 12-week period. Cannabidiol treatment reduces seizures The 261 participants mostly children with an average age of 11 years had severe epilepsy that had not responded adequately to other treatments. Epidiolex was given in gradually increasing doses alongside current AED treatment regimes of which patients were taking an average of three.

Right arrow indicates rick simpson oil solvents vacuole filled with degrading organelles. Panel d double-membraned vacuole fusing with lysosome (indicated by double-headed arrow). Arrow heads indicate empty vacuoles.

Styryl sulfonyl Cannabinoid Meeting 2014 compounds cannabidiol vaping with emphysema inhibit translation of Cannabinoid Meeting 2014 cyclin D1 in mantle cell lymphoma cells. Oncogene 2009;28:1518-28. Role of mitochondria as the gardens of cell

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death. Cancer Chemother Pharmacol 2006;57:545-53.

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CBD oils – a strain of medical marijuana – now legal in North Ca – WBTV 3 News Weather Sports Traffic Charlotte NC 2015-07-17T05:07:31Z 2015-08-16T09:27:08Z RALEIGH NC (WBTV) – Governor Pat McCrory signed North Carolina’s CBD oil bill late Thursday afternoon. Cbd Hemp Oil Side Effects there was no fanfare no press release and no major announcement. HB 766 is law.

If you’re prone to acne you’ll want to use hemp oil only for removing makeup and then finish with an apple cider vinegar/lemon juice toner which hemp oil 0.5 gm cannabis oil legal status uk review cbd will help cleanse the skin of excess oil and bacteria but won’t promote dryness. Hemp oil is better to use than makeup removers because it’s very nourishing to the skin and won’t strip away good oils the skin needs to actually fight bacteria. When the skin becomes too dry and undernourished harmful bacteria can make their way into the pores. Dead skin from dryness can cause bacteria to fester which in turn can lead to acne. Using harsh creams can create a vicious cycle that further dries the skin and makes things worse.

At present inflammation a common denominator among the Cbd Hemp Oil Side Effects diverse list of neurodegenerative diseases cannabis detox side effects review has been implicated as a critical mechanism that is responsible for the progressive nature of neurodegeneration. Since at present

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there are few therapies for the wide range of neurodegenerative diseases scientists are still in search of new therapeutic approaches to the problem. An early contribution of neuroprotective and antiinflammatory strategies for these disorders seems particularly desirable because isolated treatments cannot be effective. In this contest marijuana derivatives have attracted special interest although these compounds have always raised several practical and ethical problems for their potential abuse.

This also makes Quigley’s a perfect choice at bedtime. Open up a bottle of Quigley’s and open up your mind. Ready to feel enlightened and uplifted? That’s the Quigley’s effect.

Results Preliminary experiments Results from the series of pilot studies see Additional file 1 determined that vaporisation of CBD at 230C was superior to 210C in terms of the quantity of CBD delivered into the balloon (Pilot study 1). A saturation effect appeared to occur at 200mg CBD with greater quantities resulting only in excessive resinous residue remaining on the liquid pad (Pilot study 2). A greater amount of CBD vapour was delivered into the XL balloon than into the standard size balloon (Pilot study 3); the amount delivered into the standard balloon was similar to that of the previous pilot study thus replicating the delivered dose of approximately 25% following the loading and vaporising of 200mg CBD.

As with everything in life marijuana should be used in moderation. Too much of anything is always a bad thing. People need to remind themselves of this more often.

Around 50000 people die each year from alcohol poisoning. Similarly more than 400000 deaths each year are attributed to tobacco smoking. By comparison marijuana is nontoxic and cannot cause death by overdose. Get the facts.

Glass fibre filters (Cambridge type borosilicate glass 92mm diameter) and tightly fitting filter holders for capturing the vapour were obtained from Borgwaldt Technik GmbH (Hamburg Germany). The Volcano vaporiser device (type Volcano ?Digit’) was obtained from Storz & Bickel GmbH & Co. (Tuttlingen Germany) and was used according to the manual as provided by the manufacturer.

Medicine is fine just as long as it doesn’t facilitate pleasure! Well I say they are dangerous fools! I say shame on them! Yeah and after a hard day of work they go to the bar and have a few drinks. Why is one buzz better than the other? Thank goodness the scientists state that the medicine works best when there is both THC and CBD in it. I WOULD argue that the THC buzz is Cbd Hemp Oil Side Effects quite a lot better depending somewhat on one’s purpose. If I want to party I would likely drink alcohol because it makes me less inhibited and so more social but if I wanted to sit around the fireplace and read a book or hang out and vege with like-minded friends I’d choose cannabis. Different drugs are better for different purposes.

There are certain places where a haze of pot smoke is to be expected: Grateful Dead concerts for example or marijuana legalization rallies. But on the streets of Rome? Yes according to a 2012 study done in Italy trace amounts of marijuana are wafting through the air around the Colosseum and the Pantheon as well as in seven other Italian cities. Researchers examined the air of Rome Bologna Florence Milan Naples Palermo Turin and Verona for psychotropic substances including cocaine marijuana nicotine and caffeine.

After a period of having a spoon of Hemp Seed Oil first thing in the morning my skin started to build up texture again. Still a long way to go but also a long way from where I was. Colon Cleanser Oxy-Powder is the top quality colon cleanser.

It does not get people cbd vape oil ebay high. Both originate from the same plant but marijuana is cultivated for the buds (which have to be carefully raised for that specific purpose). They’re also grown differently.

We have facilitated the comfort of participants inhaling CBD vapours by offering small sips of water or juice ice or sweets to suck and soothe the irritation or tetrahydrocannabinol (thc) side effects sometimes unmedicated cough lozenges. Further the dense vapours produced by CBD are visibly different to order cannabinoid receptor 2 structure the less dense vapours produced by THC. It is recommended for blinding purposes to mask these differences by covering the balloon (e.g. with an opaque plastic bag or fabric cover). Declarations Acknowledgements Cbd Hemp Oil Side Effects Electronic supplementary material Competing interests All authors declare that they have no competing interests.